The signal matters.
So does the connection.
Explore the scientific rationale behind the PDGF MATRIX design—and the distinction between a promising technology and a validated finished product.
Purposeful science.
Clearly explained.
Two distinct areas of recombinant-protein thinking within the Epi-Glo family.
Stability. Release.
Skin delivery.
FGF FUSION + IGF FUSION.
A different focus.
Matrix affinity.
Recombinant PDGF-BB with a PlGF-derived binding domain, designed around association with the extracellular matrix.
More than the molecule.
Its connection to the matrix.
PDGF-BB
Platelet-derived growth factor-BB is the signaling protein at the center of the PDGF MATRIX concept. Recombinant production defines the starting molecule.
A PlGF-derived domain
A matrix-binding domain is incorporated into the design. “PlGF-derived” describes its biological inspiration, not the use of placental tissue.
Local association
The development goal is stronger association with extracellular-matrix components. Binding, retention, activity and formulation performance must be assessed for the actual product.
| Design question | Unmodified PDGF-BB | PDGF MATRIX concept |
|---|---|---|
| Protein design | PDGF-BB without the added PlGF-derived domain. | PDGF-BB incorporating a PlGF-derived matrix-binding domain. |
| Matrix interaction | Properties depend on the protein form and formulation. | Designed for enhanced matrix affinity; product-specific testing is needed. |
| Clinical comparison | Evidence belongs to the specific studied product and use. | No demonstrated human superiority over Ariessence or other PDGF products is claimed. |
Molecular design is not a substitute for evidence of safety, efficacy, skin penetration or post-procedure suitability.
Extracellular-matrix affinity as a design strategy.
Martino and colleagues studied growth factors engineered with a PlGF-derived domain. Their rodent studies support further investigation of this approach. They did not test Epi-Glo PDGF MATRIX or compare it with Ariessence.
Read the 2014 Science paper ↗The signal matters.
So does the connection.
PDGF MATRIX is designed to add matrix affinity to PDGF-BB. The goal: a stronger association with the surrounding extracellular environment.
Understand the design difference →Illustrative schematic · Not to scale
Let’s make
a connection.
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